Academic Program

Program

Thursday, October 27, 2022

[8:00-8:15] Welcome to IWWM-11

Jesus San Miguel, Ramon Garcia Sanz, and Steven Treon [Workshop Organizers]

 

 

 

[8:15-9:30] Session I 

WM Predisposition

Mary McMaster, Alessandra Trojani [Chairs]

 

GWAS Study Findings in Familial Plasma Cell Dyscrasias incl. WM

Mary McMaster, National Institutes of Health, USA

 

Clonal Lymphopoiesis and predisposition to WM

Bruno Paiva, University of Navarra, Spain

 

Common gene set signature in IGM MGUS and WM by transcriptome analysis

Alessandra Trojani, Ospedale Metropolitano Niguarda, Italy

 

Twin Genomic Studies in WM: Identification of FHL2 Gene Mutation

Jian Hou, Renji Hospital, Shanghai Jiao Tong University, China

 

Clonal Hematopoiesis and risk of WM Progression

Adam Sperling, Dana Farber Cancer Institute, USA

 

[9:15] Panel Discussion, All Session I Speakers

 

 

[9:30-10:00] Morning Break

 

 

[10:00-11:30] Session II

WM Genomics I

Bruno Paiva, Zachary Hunter [Chairs]

 

Comprehensive WES Study of WM-300 project

Zachary Hunter, Dana Farber Cancer Institute, USA

 

Genomic differences in WM single cells

Cristina Jiménez, University of Salamanca, Spain

 

Integration of cytogenetic and molecular screening for first line patients

Damien Roos-Weil, Hôpital Pitié-Salpêtrière, France

 

Genomic Variants in Chinese Patients with WM

Shuhua Yi, Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

 

Lon Non-Coding RNA Expression in IGM MGUS and WM

Jonas Paludo, Mayo Clinic, USA

 

Single Cell Analysis of MYD88 mutated and wild-type WM

Tina Bagratuni, University of Athens, Greece

 

[11:15] Panel Discussion, All Session II Speakers

 

 

[11:30-12:45] Session III

WM Genomics II

Marzia Varettoni, Nikhil Munshi [Chairs]

 

DNA Methylation Profiling in WM

Damien Roos-Weil, Hôpital Pitié-Salpêtrière, France

 

Genomic studies in WM: first results from the BIOWM study of Fondazione Italiana Linfomi (FIL)

Marzia Varettoni, University of Pavia, Italy

 

Distinct Genomic Profile Characterizes IGM MM from WM

Nikhil Munshi, Dana Farber Cancer Institute, USA

 

Genomic Landscape of WM reveals late developing CNA

Kylee MacLachlan, Memorial Sloan Kettering Cancer Center, USA

 

Proteomic and Metabolomic Studies in WM

Shahrzad Jalali, Mayo Clinic, USA

 

[12:30] Panel Discussion, All Session III Speakers

 

 

[12:45-13:45] LUNCH

 

[13:45-15:00] Session IV

Transgenic Models for WM

Ruben Carrasco, Jose Martinez-Climent [Chairs]

 

MYD88 Transgenic Model

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany

 

MYD88 L265P Transgenic Model

Ruben Carrasco, Dana Farber Cancer Institute, USA

 

Unraveling and targeting the immune microenvironment in MYD88 lymphomas

José Martínez-Climent, University of Navarra, Spain

 

Continuous activation of mutated MYD88

Christelle Vincent-Fabert, UMR CNRS/INSERM, France

 

CXCR4 Transgenic Model

Marion Espeli, Inserm Unité Mixte de Recherche S996, France

 

[14:45] Panel Discussion, All Session IV Speakers

 

 

[15:00-15:30] Afternoon Break

 

 

[15:30-16:45] Session V

Signalomics in WM

Irene Ghobrial, Aldo Roccaro [Chairs]

 

MYD88 driven HCK pro-survival signaling

Guang Yang, Dana Farber Cancer Institute, USA

 

Mutated MYD88 related ubiquitination

Yong Li, Baylor College of Medicine, USA

 

ERK dysregulation mediated by aberrant WNK2 expression

Maria Luisa Guerrera, Dana Farber Cancer Institute, USA

 

FGF/FGF-R Axis in MYD88 Mutated WM

Aldo Roccaro, ASST Spedali Civili di Brescia, Italy

 

Genomic evolution of ibrutinib resistant clones

Cristina Jiménez, University of Salamanca, Spain

 

[16:30] Panel Discussion, All Session V Speakers

 

[16:45-17:45] Session: VI

Plenary Session I

Monique Minnema, Ramon Garcia Sanz [Chairs]

WM013 Non-invasive screening of MYD88L265P mutation by droplet digital PCR in IgM gammopathies: Results of the multicentric “BIOWM” trial of the Fondazione Italiana Linfomi (FIL).

Martina Ferrante, University of Torino, Italy

 

WM017 Genomic pathways differentiating IgM-MGUS from Waldenstrom Macroglobulinemia: The integrated microRNA and gene expression landscape.

Karan Chohan, Mayo Clinic, USA

 

WM020 Molecular clusters and tumor-immune drivers of IgM monoclonal gammopathies.

Patrizia Mondello, Mayo Clinic, USA

 

WM006 T-regulatory cell mediated immunosuppression plays a pivotal role in supporting Waldenstrom macroglobulinemia pathogenesis.

Aldo Roccaro, ASST Spedali Civili di Brescia, Brescia, Italy

 

[17:30] Panel Discussion, All Session VI Speakers

 

 

 

[17:45-18:00] Keynote Lecture

 

What the genomics of WM tells us about its curability

Keynote Speaker: Steve Treon, Dana Farber, USA

 

 

[18:00] Poster Presentations and Reception

 

 

[19:30] Dinner Reception and Opening Ceremonies

 

  • Keynote Speaker: Marvin Stone, MD, MACP, FRCP

History of Waldenstrom’s Macroglobulinemia

  • Presentation of Young Investigator Awards
  • Presentation of Robert A. Kyle Awards

Friday, October 28, 2022

[8:00-9:15] Session VII

Prognostic and Predictive Markers

Prashant Kapoor, Efstathios Kastritis [Chairs]

 

Models-Risk Stratification of Asymptomatic WM

Romanos Sklavenitis-Pistofidis, Dana Farber Cancer Institute, USA

 

Predictors of Short Survival in WM

Prashant Kapoor, Mayo Clinic, USA

 

Impact of 6q on WM clinical outcomes

Ramón García-Sanz, University of Salamanca, Spain

 

CXCR4 subtype and clonality impact ibrutinib response

Joshua Gustine, Dana Farber Cancer Institute, USA

 

Prognostic Impact of MYD88 L265P by ddPCR

Carlos Fernández de Larrea Rodríguez, Hospital Clinic Barcelona, Spain

 

[9:00] Panel Discussion, All Session VII Speakers

 

  

[9:15-10:45] Session VIII

Chemoimmunotherapy

Veronique Leblond, Jorge Castillo [Chairs]       

 

B-RCD vs. RCD Randomized Trial in WM

Pierre Morel, Centre Hospitalier Universitaire Amiens Picardie, France

 

RCD vs BCD Randomized Trial

Lugui Qiu, National Clinical Research Center for Blood Diseases, China

 

Bendamustine/Rituximab: Dose Intensity and Patient Outcomes

Suzanne Arulogun, UC London Hospitals NHS, UK

 

FILO Bendamustine Rituximab Study

Véronique Leblond, Hôpital Pitié Salpêtrière, France

 

STIL Maintenance Rituximab

Mathias Rummel, University of Giessen, Germany

 

BRB: Bendamustine, Rituximab, Bortezomib Study: Fondazione Italiana Linfomi Study

Giulia Benevolo, University of Torino, Italy

 

[10:30] Panel Discussion, All Session VIII Speakers

 

[10:45-11:15] Morning Break

 

[11:15-12:30] Session IX

BTK-Inhibitors I

Judith Trotman, Meletios Dimopoulos [Chairs]

 

Long Term Follow-Up of Ibrutinib Monotherapy in WM

Jorge Castillo, Dana Farber Cancer Institute, USA

 

Long Term Follow-up of the INNOVATE Study

Christian Buske, University Hospital Ulm, Germany

 

Comparative outcomes of Ibrutinib and Bendamustine in treatment naïve patients

Jithma Abeykoon, Mayo Clinic, USA

 

Real World Experiences with Ibrutinib-UK experience

Shirley D’Sa, UC London Hospitals NHS, UK

 

Real World Data on CIT and BTK-inhibitors: WHIMSICAL Study

Ibrahim Tohidi-Esfahani, University of Sydney, Australia

 

[12:15] Panel Discussion, All Session IX Speakers

 

[12:30-13:30] LUNCH

 

[13:30-14:30] Session X

BTK-Inhibitors II

Alessandra Tedeschi, Constantine Tam [Chairs]

 

Long Term Follow-up-Acalabrutinib Phase II

Roger Owen, Leeds Hospital NHS Trust, UK

 

Long Term Follow-Up Zanubrutinib-Phase II

Judith Trotman, University of Sydney, Australia

 

Phase II Zanubrutinib in relapsed/refractory WM: Chinese experience

Lugui Qui, National Clinical Research Center for Blood Diseases, China

 

Phase II study of Zanubrutinib, Ixazomib and Dexamethasone

Shuhua Yi, Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

 

[14:15] Panel Discussion, All Session X Speakers

 

[14:30-15:30] Session: XI

Plenary Session II

M.J. Kersten, Christian Buske [Chairs]

WM004 Final results of the Phase I/II Hovon 124/ECWM-R2 Study including 2 year rituximab maintenance after induction with ixazomib, rituximab and dexamethasone in relapsed Waldenstrom’s Macroglobulinemia.

Karima Amaador, UMC Medical Center, University of Amsterdam, Netherlands

 

WM042 ASPEN: Long term follow-up results of a Phase 3 randomized trial of zanubrutinib versus ibrutinib in patients with Waldenstrom Macroglobulinemia.

Meletios Dimopoulos, University of Athens, Greece

 

WM041 ASPEN Biomarker analysis: Response to BTK inhibitor treatment in patients with Waldenstrom Macroglobulinemia harboring CXCR4, TP53, and TERT mutations.

Constantine Tam, Peter MacCallum Cancer Center, Australia

 

WM024 Identification of robust predictors for ibrutinib response by multi-omic genomics in MYD88 mutated Waldenstrom’s Macroglobulinemia.

Kris Richardson, Dana Farber Cancer Institute, USA

 

[15:15] Panel Discussion, All Session XI Speakers

 

[15:30-16:00] Afternoon Break

 

[16:00-17:15] Session: XII

Management of covalent BTK-inhibitor exposed patients

Shayna Sarosiek, Carlos De Larrea [Chairs]

 

Dose reduction of ibrutinib and impact on treatment course

Shayna Sarosiek, Dana Farber Cancer Institute, USA

 

Zanubrutinib in patient’s intolerant to ibrutinib/acalabrutinib

Mazyar Shadman, Fred Hutchinson Cancer Res Center, USA

 

Venetoclax in Previously Treated WM incl. BTK-inhibitor exposed patients

Jorge Castillo, Dana Farber Cancer Institute, USA

 

Pirtobrutinib in Previously Treated WM Patients with Covalent BTK-inhibitor

  1. L. Palomba, Memorial Sloan Kettering Cancer Center, USA

 

MK-1026 Dose Expansion Study in B-cell malignancies incl WM

Deborah Stephens, University of Utah, Huntsman Cancer Institute, USA

 

[17:00] Panel Discussion, All Session XII Speakers

 

[17:15-17:45] Keynote Lectures

 

Mechanistic Insights into Adverse Events underlying BTK-inhibitors

Keynote Speaker: C.I. Edvard Smith, Karolinska Institut, Sweden

 

Targeting the Epigenome: Opportunities for WM

Keynote Speaker: Ari Melnick, Cornell University, USA

 

[17:45] Day Adjournment

 

[18:30] Faculty Dinner Reception

Saturday, October 29, 2022

[8:00-11:15] Session XIII

Great Debates in WM

Eva Kimby, Jesus San Miguel [Chairs]

 

[8:00-8:30] Great Debate I

Should we treat smoldering WM? -No

Prashant Kapoor, Mayo Clinic, USA

 

Should we treat smoldering WM? -Yes

Irene Ghobrial, Dana Farber Cancer Institute

 

[8:30-9:00] Great Debate II

Should BTK-I or Benda-R be the standard frontline induction regimen? -for Benda-R

Christian Buske, University Hospital Ulm, Germany

 

Should BTK-I or Benda-R be the standard frontline induction regimen? -for BTK-I

Meletios Dimopoulos, University of Athens, Greece

 

[9:00-9:45] Great Debate III

Does the choice of BTK-inhibitor matter? -for Ibrutinib

Ranjana Advani, Stanford University Medical Center, USA

 

 

 

Does the choice of BTK-inhibitor matter? -for Acalabrutinib

Roger Owen, Leeds Hospital NHS Trust, UK

 

Does the choice of BTK-inhibitor matter? -for Zanubrutinib

Judith Trotman, University of Sydney, Australia

 

[9:45-10:15] Morning Break

 

[10:15-10:45] Great Debate IV

Managing the ibrutinib intolerant patient: Dose reduce or switch to another BTK-inhibitor? -Dose reduce

M Lia Palomba, Memorial Sloan Kettering Cancer Center, USA

 

Managing the ibrutinib intolerant patient: Dose reduce or switch to another BTK-inhibitor? -Switch

Alexandra Tedeschi, Niguarda Hospital, Italy

 

[10:45-11:15] Great Debate V

What should be the end point of therapy in WM? -Disease control should be the endpoint of therapy

Stathis Kastritis, University of Athens, Greece

 

What should be the end point of therapy in WM? -CR should be the endpoint of therapy

Jorge Castillo, Dana Farber Cancer Institute, USA

 

[11:15-12:15] Session XIV

Novel Treatment Approaches to WM-Clinical I

Sheeba Thomas, Moshe Gatt [Chairs]

 

Venetoclax in combination with ibrutinib for WM

Jorge Castillo, Dana Farber Cancer Institute, USA

 

Targeting mutated CXCR4 in WM

Steven Treon, Dana Farber Cancer Institute, USA

 

Obinutuzumab and Idelalisib in WM

Véronique Leblond, Hôpital Pitié Salpêtrière, France

 

Acalabrutinib and Rituximab for WM and IGM RD PN

Shayna Sarosiek, Dana Farber Cancer Institute, USA

 

[12:00] Panel Discussion, All Session XIV Speakers

 

 

 

[12:15-13:00] Session XV

Novel Treatment Approaches to WM-Clinical II

Jorge Castillo, Stephen Ansell [Chairs]

 

Tirabrutinib in Treatment Naïve and Previously Treated WM

Koji Izutsu, National Cancer Center Hospital, Japan

 

Phase II study of Orelabrutinib in relapsed/refractory WM

Xinxin Cao, Peking Union Medical College, China

 

Clinical Activity of IRAK4 Inhibitor CA-4948 in NHL, incl. WM

Reinhard Von Roemeling, Curis Pharmaceuticals, USA

 

[12:50] Panel Discussion, All Session XV Speakers

 

[13:00-14:00] LUNCH

 

[14:00-15:00] Session XVI

Novel Treatment Approaches to WM-Clinical III

Merav Leiba, Shirley D’Sa [Chairs]

 

Bispecifics in WM-CD3XCD20 RGN1979

Stephen Ansell, Mayo Clinic, USA

 

Phase II Study of Loncastuximab in WM

Shayna Sarosiek, Dana Farber Cancer Institute, USA

 

Idiotype DNA Vaccine Therapy for WM

Sheeba Thomas, MD Anderson, USA

 

CD20 CAR-T therapy for WM and other B-NHLs

Mazyar Shadman, Fred Hutchinson Cancer Res Center, USA

[14:45] Panel Discussion, All Session XVI Speakers

 

 

[15:00-15:30] Keynote Lectures

 

Bi-specifics and Conjugated Antibodies: MM Experience

Keynote Speaker: Kenneth C. Anderson, Dana Farber Cancer Institute, USA

 

Bringing CART to WM: Which One?

Keynote Speaker: Nikhil Munshi, Dana Farber Cancer Institute, USA

 

[15:30-16:00] Afternoon Break

[16:00-16:45] Session XVII

Special Topics Lectures

 

Clinical Characteristics and Outcomes with Cryoglobulinemia in WM

Speaker: Shirley D’Sa, UC London Hospitals NHS, UK

 

Clinical Characteristics and Outcomes with Cold Agglutinins in WM

Speaker: Josephine Vos, University of Amsterdam, Netherlands

 

Management of Amyloidosis in WM Patients

Speaker: Giampaolo Merlini, University of Pavia, Italy

 

[16:35] Panel Discussion, All Session XVII Speakers

 

[16:45] Day Adjournment

[18:30] Dinner Reception and Closing Ceremonies

 

  • Keynote Speaker: Meletios Dimopoulos, MD

Challenges of WM Patient Care in the Era of Covid

  • Presentation of Peter S. Bing Humanitarian Awards
  • Presentation of Jan Gosta Waldenstrom Awards
  • Announcement and Welcome to IWWM-12

Sunday, October 30, 2022

[8:00-9:15] Session XVIII

COVID and WM

Ramón García Sanz, Andrew Branagan [Chairs]

 

Responses to COVID vaccination in WM and MM Patients

Andrew Branagan, Massachusetts General Hospital, USA

 

Responses to COVID vaccination (initial and booster dose) in patients with plasma cell neoplasms

Evangelos Terpos, University of Athens, Greece

 

GETH-TC Study on Serological responses to initial vaccination and booster in heme patients

with /without prior COVID19

Ramón García-Sanz, University of Salamanca, Spain

 

Efficacy of BNT162b2 in WM and FLL -Australian Experience

Judith Trotman, University of Sydney, Australia

 

Impact of Booster Vaccination on SARS-COV-2 Antibody Levels in Blood CA Patients incl. WM

Lee Greenberger, Leukemia Lymphoma Society, USA

 

[9:00] Panel Discussion, All Session XVIII Speakers

 

 

[9:15-9:45] Session XIX

Clinical Trials in Progress

Constantine Tam, Efstathios Kastritis [Chairs]

 

European Trials in Progress

M.J. Kersten, UMC Medical Center, University of Amsterdam, Netherlands

 

North American Trials in Progress

Jorge Castillo, Dana Farber Cancer Institute, Boston MA USA

 

 

[9:45-10:00] Morning Break

 

[10:00-13:00] Session XX

WM Panel Discussions and Sunday Brunch

Addressing the Key Questions in WM Management

Steve Treon, Meletios Dimopoulos [Moderators]

 

WM Consensus Panel I

IWWM-11 Recommendation for Treatment Approach in WM-Frontline

Organizers: Christian Buske, Jorge Castillo, Judith Trotman

 

WM Consensus Panel II  

IWWM-11 Recommendation for Treatment Approach in WM-Relapsed/Refractory

Organizers: Efstathios Kastritis, Shirley D'SA, Jeffrey Matous

 

WM Consensus Panel III  

IWWM-11 Recommendation for Molecular Diagnostic Workup in WM

Organizers: Ramón García-Sanz, Marzia Varettoni, Zachary Hunter

 

WM Consensus Panel IV  

Response Criteria for WM

Organizers: Steve Treon, Roger Owen, Alessandra Tedeschi

 

WM Consensus Panel V  

COVID Prophylaxis and Management in WM

Organizers: Meletios Dimopoulos, Véronique Leblond, Andrew Branagan

 

WM Consensus Panel VI  

Management of WM-related Amyloidosis

Organizers: Monique Minnema, Shayna Sarosiek, Giampaolo Merlini

 

WM Consensus Panel VII  

Priorities for Novel Clinical Trials

Organizers: MJ Kersten, Prashant Kapoor, Constantine Tam

 

[13:30] Meeting Adjournment

The Bing Center

ing Center for Waldenstrom's Macroglobulinemia
Dana Farber Cancer Institute
Harvard Medical School

Contact

Christopher Patterson
Secretariat

Address

450 Brookline Avenue

Mayer 548

Boston, MA 02215

p +1 617 632 6285

f +1 617 632 4862

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